Evaluation The Role of CD33+ CD11b+ myeloid-derived Suppressor Cells in Patients With AML

Acute myeloid leukemia is a genetically heterogeneous clonal disease defined by the accumulation of immature cells in bone marrow and blood. The aim this study to evaluate CD33, CD11b, HLA-DR expression Iraqi AML patients its role evasion malignant from immune system. This was conducted on 60 with 20 healthy individuals as control group CD33 CD11b using flow-cytometry peripheral blood, Interferons-γ (IFN-γ) Transforming Growth Factor-β1 (TGF-β1) levels. A statistically non-significant difference (P < 0.005) between regard observed. Analysis myeloid-derived suppressor (MDSCs) showed significant decrease proportion positive MDSC isolated blood samples (88.078 ± 1.284). Also, high (98.841±1.935) cells. mean level IFN-γ (pg/ml) increased compared (9.202 0.244), (7.906±1.22), respectively. While TGF- β1 concentration found be elevated (69.04 9.92) (33.884 2.888). In conclusion, circulating MDSCs were significantly characterized CD33+CD11b + phenotype; TGF-β1 can released presence native human affect cell proliferation